| TapNPay allows toll road authorities to read a license plate then bill the user, virtually. The platform is currently available to about 60% of US toll road traffic, with more expansion in the works. TapNPay leverages Direct Carrier Billing (payments directly from cellphone accounts), PayPal, and digital wallets such as Apple Pay and Google Pay to link license plates directly with a toll user’s payment information. No paper bills or physical payment via check or cash required.Austin, TX
Invested November 2022 Fund IV |
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The Digital Strand offers an end-to-end security platform for sharing data as part of data-analysis projects and data sales, focusing initially on the oil and gas industry. The system limits and tracks the use of data and can also monitor any analysis products resulting from the data. The Digital Strand has two patents pending, one for maintaining digital-rights management for data used with third-party software on third-party hardware, and one for identifying analogous data without exposing the original data or metadata.Houston, TX
Invested November 2022 Fund IV |
| The Flourish Fund has created the first wellness focused baby registry. They allow families to register for things like labor doulas, baby doulas, lactation consultants, night nannies, and sleep consultants. Flourish Fund exists to solve the problem of mothers struggling to care for themselves during pregnancy and postpartum.Newport, RI
Invested August 2022 Fund IV |
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Drusolv Therapeutics, Inc. is a clinical-stage drug company focused on development of a repurposed, very high-dose statin for early intervention in a blinding eye disease called age-related macular degeneration (AMD). There are currently 9.5 million cases of dry, early-stage AMD in the US and Canada. There is no effective therapy for onset of early “dry” AMD.Philadelphia, PA
Invested May 2022 Fund IV |
| Dynamic Light’s imaging technology provides surgeons with continuous, real-time blood flow visualization without dyes or procedural interruptions. Their technology supports better decision making, improves patient care and reduces health care costs.Austin, TX
Invested February 2022 Fund IV |
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Global Neighbor has developed the Weed Seed Destroyer that attaches to a farm combine and uses short durations of high intensity, dual wavelength light to kill weeds and sterilize their during harvest. They call their technology directed energy (DE) floral control. The Weed Seed Destroyer addresses the growing problem of herbicide resistant weeds.Dayton, OH
Invested December 2021 Fund IV |
| Vartega has developed a low-cost grade of carbon fiber through the use of its patented recycling process. This carbon fiber has mechanical properties similar to virgin material. Vartega’s recycled fibers are used in broad ranging applications including nonwoven fabrics, thermoplastic pellets, and 3D printing filaments.Golden, CO
Invested November 2021 Fund IV |
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Rx Bandz has developed the next generation of patient-centric auto-injectors able to deliver a wide range of injectable medication for active civilian and military patients around the world.Long Island, NY
Invested October 2021 Fund IV |
| Resonant Therapeutic supports the drug discovery sector with a proprietary laboratory tool, IMPaCT (Integrated Microenvironment Pathway Catalog and Triage). The IMPaCT platform combines proprietary tumor models with targeted antibody-based discovery to identify tumor-selective targets and potential therapeutics that are missed by traditional approaches. Therapeutic antibodies (for example, Humira) are applicable to a wide range of diseases and are the largest class of commercial drug therapies on the market currently. Resonant’s business model is to identify new disease targets and drug candidates and to license to large pharmaceutical companies.Houston, TX
Invested October 2021 Fund IV |
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ReturnSafe is transforming healthcare through the power of prevention. They do this by enabling organizations including employers, schools, concert venues, sports arenas, and more to keep spaces open and their occupants healthy and safe with preventative and early detection measures.Austin, TX
Invested September 2021 Fund IV |
| Work & Mother provides a network of fully equipped lactation facilities that not only supports working mothers but makes it easy for employers to be in compliance with Fair Labor Standards Act regulations and allows landlords to provide an additional amenity for their tenants. This combination results in happier employees and less attrition for companies and a more satisfied, stable tenant base.Houston, TX
Invested July 2021 Fund IV |
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Materna Medical is an early-stage medical device company located in the San Francisco Bay area of California. Materna’s goal is improve female health. Prep, its primary product, is a clinical device that reduces the incidence of childbirth-related injuries to women during vaginal delivery by pre-stretching the birth canal. The unique effect expedites birthing and reduces muscle tearing, with both immediate and significant long-term benefits. A second product, Milli, address pelvic spasming in its many forms and is for sale OTC currently. Materna Medical Inc. was initially developed within the Stanford University Biodesign Program, a program whose goal is to develop technology to address major unmet clinical needs.Mountain View, CA
Invested December 2013 and April 2021 Funds I and IV |
| CellChorus provides high throughput, dynamic analysis of single cells. At a research level, the Company’s TIMING™ platform applies visual AI to evaluate cell motility and activity as a function of time in order to maximize understanding of cellular function, state, and phenotype. Therapeutically, CellChorus is used to assess immuno-oncology potential in customized T regulatory cell re-infusion therapy preparations.Houston, TX
Invested March 2021 Fund IV |
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Electrast™, by Sonnest, is the only electrically sensitive contrast agent for ultrasound imaging of cardiac structure, function and perfusion. Electrast™ is a patented, nano particle construct, enveloping a perfluorocarbon liquid within a phopholipid-based liposome. The agent activates only upon ultrasonic excitation in the presence of the electrical field associated with functioning, perfused heart muscle. Activation takes the form of a liquid to gas phase change of the perfluorocarbon at characteristic ultrasonic frequency. In the absence of both conditions, Electrast™ freely circulates through the bloodstream in an inactive state, transparent to imaging.Philadelphia, PA
Invested March 2021 Funds III & IV |
| Chosen Diagnostics, Inc. is focused on identifying and developing biomarkers into commercial diagnostic systems. An initial product, NECDetect, is a unique diagnostic for necrotizing enterocolitis (NEC), a particularly devastating condition in pre-term infants. NECDetect been designated by the FDA to have both orphan and breakthrough status, potentially expediting FDA approval. Chosen has successfully competed in several pitch competitions, and is the awardee of several National Institute of Health funding grants. NECPredict is Chosen’s second generation product. HALO led Chosen’s initial 2020 funding round. New Orleans, LA
Invested December 2020 Exited September 2023 Fund IV |
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Connectus Global is a provider of an ultra-wide band (UWB) based real-time location monitoring system (RTLS) along with an electronic permit to work (E-PTW) software solution. With an integrated suite of digital workforce management and business continuity systems, the company’s globally deployed solutions work to enhance safety, operational efficiency and crisis recovery planning. The UWB technology improves accuracy and has less interference compared to WiFi and Bluetooth. The company’s offerings address a large and growing total addressable market, serving sectors such as Energy, Industrial, Manufacturing, Mining, Healthcare, Media / Entertainment etc. Certifications (Zone 0 / Class 1 Div 1 / Class 1 Div 2 etc.) allow Connectus’ solution to be deployed in environments such as offshore platforms, floating production storage and offloading facilities, refineries, petrochemical plants etc.Calgary, Alberta, Canada
Invested December 2020 Funds III & IV |
| ImmunoGenesis, Inc. is a cancer therapeutics startup based in Houston, TX, focused broadly on immuno-oncology. The company has licensed a significant drug portfolio, much from M.D. Anderson, resulting in three primary therapeutic pipelines. The thrust of the company’s efforts is to clinically validate new drugs candidates, optimizing them for treating the many cancers that are non-responsive (i.e. “cold” tumors) to current immunotherapies – the current state of the art. Clinical studies are commencing in 2021. Exit potential is enhanced by the company’s broad IP protection, multi-drug portfolio, management breadth, and recent trends in the therapeutics marketplace.Houston, TX
Invested December 2020 Funds III & IV |
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TrueSpot is using RTLS and technology to improve the operational efficiency of automobile dealerships. Their suite of solutions is transforming dealer operations and driving significant quantifiable bottom line results utilizing their proprietary geolocation solutions which range from key and car locating to inventory management and service/reconditioning tracking and alerts.Plano, TX
Invested October 2020 Funds III & IV |
| Nexus AI is a cloud-based platform that recommends the teams and individuals most likely to succeed across all projects. Powered by artificial intelligence and organizational behavior science, Nexus AI offers the next-generation of workforce management.Chicago, IL
Invested September 2020 Funds III & IV |
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Rellevate is a Connecticut-based digital fintech company offering an innovative, employer-based digital account and financial services platform to help hourly workers cope with issues that often lead to late fees, bank overdraft fees and the use of expensive payday lenders. The services include a Digital Bank Account, a Pay-Any-Day feature, Bill Pay and the ability to Send Money, all without high fees.Darien, CT
Invested August 2020 Funds III & IV |
| MFB Fertility has developed and is selling an over the counter, at home test strip for assaying the hormone progesterone. The tests are branded as Proov and compete only with clinically administered blood tests. This is a unique product with applications in fertility monitoring, pregnancy care, and, eventually, menopause management. Proov empowers women with immediate results that are actionable in several ways.Boulder, CO
Invested August 2020 Funds III & IV |
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Renovion is a pharmaceutical development company focused on obtaining FDA approval for ARINA-1, an inhaled therapeutic regime uniquely formulated to reduce pulmonary inflammation and to thin thick mucus, facilitating clearance. The derisked technology is unique to the regulated market, can be stacked with existing therapies, is composed of three FDA approved chemicals, and has had successful first-in-man trials. ARINA-1 targets lung congestion in its many forms, an exceptionally large therapeutic opportunity.Chapel Hill, NC
Invested April 2020 Fund III |
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Path Ex offers technology that removes bacteria and possibly some of their endotoxins from a patient’s blood. The Path Ex technology physically separates pathogens from whole blood based on physical characteristics and through antibody attraction. Path Ex’s technology can be used both for diagnostic purposes, allowing physicians to identify bacterial infections, and as a sepsis therapy, removing toxins from the patient’s body.Nashville, TN
Invested February 2020 Fund III |
| PyrAmes uses a unique technology to enable noninvasive, continuous blood pressure monitoring. Their current early version demonstrates acceptable accuracy in a cuff-like device to potentially replace the arterial line now used to monitor blood pressure in small children without the risks of infection, bleeding and clotting currently encountered. In the future, it may have potential to provide continuous monitoring on adults, replacing the intermittent monitoring via blood pressure cuff used on most adults.Cupertino, CA
Invested January 2020 Fund III & IV |
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kegg is a 2 in 1 fertility tracker produced by Lady Technologies that helps detect ovulation up to 7 days in advance. The FDA-approved device is used for a few minutes every day and leverages advanced medical technology to sense changes in cervical fluid. Data is sent to the cloud where it is processed through personalized algorithms. The user’s fertility results are displayed in the kegg app in an easy to understand graph. kegg gives women an insight into their health and control over their own fertility.San Francisco, CA
Invested December 2019 Funds II and III |
| Osperity provides a computer vision platform that transforms images and video into actionable enterprise intelligence. Osprey’s AI-powered industrial IoT devices are robust and hardened for adverse conditions, and its cloud platform can be tailored to provide custom alerts for a customer’s specific needs. Edge computing capabilities filter out circumstances that do not trigger alerts, reducing data transmission expense.Houston, TX
Invested November 2019 Funds II and III |
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Ikonopedia is a SaaS company with a cloud-based radiology platform for tracking and monitoring breasts. Designed as a closed-loop system, Ikonopedia enables physicians to keep track of every lesion to resolution. Its robust and flexible data structure allows for the storage of indefinite number of lesions and follow-ups for a patient, monitors 3,200 discrete data points, and features multiple risk-assessment options as well as automatic warnings and alerts that maximize patient safety and minimize medical error.Dallas, TX
Invested October 2019 Funds II and III |
| Galen Data provides an FDA approved, HIPAA compliant cloud based platform to allow medical devices to connect to the internet at a fraction of the cost of developing a custom cloud solution. Developed as a SaaS model, the platform generates recurring revenue but allows extensive customization and scalability for the customer. Cloud based analytics as well dashboards for patients, physicians and the device manufacturer further add value for the device manufacturer.Houston, TX
Invested October 2019 Funds II and III |
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Allotrope Medical is a simple platform technology using patent pending electrical stimulation to generate a visible contraction in the ureter and other smooth muscles during surgery. A contraction allows for immediate visual identification, enabling surgeons to proceed with operations safely and quickly. The StimSite system allows the surgeon to easily switch between electrocautery and smooth muscle stimulation. Form the surgeon’s side, there are no new instruments added to the surgical field with StimSite seamlessly built in to existing laparoscopic and robotic instruments.Houston, TX
Invested July 2019 Exited April 2023 Funds II and III |
| Machfu provides hardware, software and application services for IIoT (Industrial Internet of Things) operations. Based in Rockville, MD, Machfu provides a communications and computing device for deployment at the network edge for translating various IoT protocols and formats into a uniform data model that facilitates ingestion and analysis in a variety of enterprise software suites. In addition, they also provide cloud-based software for management of the devices across the whole population. This includes communications management, applications management and security updates. This management software is the recurring revenue source for the company in the coming years.Rockland, MD
Invested June 2019 Funds II and III |
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Ictero Medical is developing the first minimally invasive cryo-ablation procedure for the treatment of gall bladder disease. The initial target market is in patients who are not general surgery candidates and for whom no definitive treatment options exist. Once validated, Ictero has the potential to address the much larger laparoscopic surgery market with their less costly procedure.Houston, TX
Invested May 2019 Funds II and III |
| Sierra.AI, is an AI SaaS company in the very large material handling safety solutions market. They are a technology platform to make material handling equipment safe and smart. Their Safety SaaS Solution can be installed on existing equipment thus extending their productivity, efficiency and safety. The technology is licensed by customers in manufacturing, logistics, distribution, retail, food/beverage vertical market segments. They serve enterprise clients that operate national fleets of material handling equipment, be it forklifts, loaders, pallet trucks etc.Invested February 2019
Funds II and III |
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MacroFab is redefining electronics manufacturing, offering the first online electronics manufacturing market place for printed circuit boards. Based in Houston, MacroFab allows customers to upload specifications for electronic systems (circuit boards), MacroFab then sources the parts required to manufacture the product, and assigns the job to a marketplace participant. MacroFab’s solution delivers unmatched price transparency, schedule certainty, and offers win-win value for owners of underutilized manufacturing capacity and customers seeking excellent, fast, reliable manufacturing of their product.Houston, TX
Invested February 2019 Fund II |
| ClearCam is a medical device company that has developed a simple, low cost, disposable laparoscope lens cleaning tool. Lens cleaning is a significant major issue in laparoscopic surgeries. Current practice generally requires repetitive tool removal from the body cavity to clean the camera lens, adding operating room time, longer anesthesia for the patient, and challenging field sterility . Depending on the length of procedure, the laparoscope may be removed as many as 30 times in a single operation. ClearCam’s solution cleans the device lens while still inside a patient, addressing an unmet need in this rapidly growing surgical field.Austin, TX
Invested December 2018 Fund II |
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| Zibrio addresses human balance. Falling with concurrent bone breakage is the most common cause of accidental death in people over 65, yet 28% of this population fall each year! Surprisingly, academic studies have proven that falling is not a natural part of aging. The best predictor of a fall is a previous fall, not age. In most cases, improvements to balance and subsequent reduction in falls follow a directed exercise routine. Zibrio’s patented technology uses a proprietary SmartScale, a deep knowledge of postural control, and the power of machine learning to measure tiny changes in balance. Once measured and quantified by the Zibrio system, balance conditioning and awareness of limitations improve patient outcomes, reducing falls and benefiting patient health.Houston, TX
Invested December 2018 Fund II |
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Your Fare aggregates delivery and take-out orders from services such as GrubHub, PostMates and Favor, and delivers the orders to restaurants on a single tablet device, or directly to the restaurant’s Point of Sale system, greatly simplifying and stream-lining the work of incorporating delivery and take-out orders into the restaurant’s workflow.Austin, TX
Invested December 2018 Funds II and III |
| ScribeRule provides software solutions to protect sensitive documents from unauthorized access, while permitting secure collaboration. With initial customers in the United States Federal Government, the company provides a comprehensive solution for document security.Houston, TX
Invested November 2018 Fund II |
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VenoStent is a medical device startup company developing a bio-absorbable external “wrap” that reinforces the surgical grafting of two blood vessels by temporarily surrounding the graft. Initially, VenoStent is addressing the dialysis market which generally relies on access ports in the arm created by surgically grafting a vein to an artery. Such grafts are commonly subject to failure, with 40 – 60% of dialysis access sites failing within a year. The SelfWrap is designed to reduce this dialysis access failure. Additional vascular surgery markets will support additional growth as the ease of use and reduction in complications become apparent.Nashville, TN
Invested November 2018 Fund II |
| TheratomeBio is developing a therapeutic platform, a secretome, derived from a standardized line of adult stem cells. In general, stem cell secretome can mimic the action of stem cells, while avoiding their unpredictable nature and difficulty in processing and administration. Activity includes pro-angiogenic (blood vessel) and pro-neurogenic (nerve) growth, and reduction in inflammation. Their lead product, Thera-101, is a first line, injectable, biologic targeting ischemic brain injury, including stroke. Many additional applications have been identified but remain under the radar as of this writing. The company is pursuing partnerships and FDA approvals.Indianapolis, IN
Invested October 2018 Fund II |
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PolyPort is a Boulder, CO-based software company that develops and sells unique software to protect digital asset ownership. The company’s initial focus is on protection of 3D printing models, where its software can limit the use of a purchased license by user, by time, by number of reproductions, etc.. However, its approach is applicable to any computer file. Protection of software assets will increase the market potential of customized software, expanding the growing 3D printing (and other) markets and stimulate commerce by ensuring payment to the software developer.Boulder, CO
Invested September 2018 Exited November 2022 Fund II |
| Riders Share is an online, peer-to-peer, motorcycle rental service, tagging itself “The Airbnb of Motorcycles.” The company connects an underperforming asset – an infrequently used recreational motorcycle for example – and monetizes it for the owner by connecting a short term renter – just as Airbnb monetizes an unused garage apartment for its owner. It works by motorcycle owners first listing their motorcycles for rent on the online platform at a specified daily rental price. Riders-share.com takes a commission on the rental, currently 30% of the gross revenue. The company also offers an optional damage waiver which covers the renter if the motorcycle is damaged.Austin, TX
Invested September 2018 Funds II and III |
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Arovia is the maker of the SPUD, the Spontaneous Pop-up Display, a collapsible folding 24” video display for cell phones and laptops. Its version 1 product is sold out. Arovia is developing version 2 of its product, for which which it expects to begin taking orders in 2020.Houston, TX
Invested September 2018 Fund II |
| GlycosBio Food Science uses proprietary biochemistry to produce molecularly unique, high Calorie nutrition benefiting patients with intestinal absorption issues. Potential applications include patients with compromised pancreatic function requiring supplementation with porcine pancreatic enzymes (pancreatitis and cystic fibrosis patients). Additional markets include the very young (neonates), the elderly, and certain cancer patients in need of supplemental Calories. GlycosBio’s technology is patent pending. We believe it has the potential to disrupt the multi billion dollar medical foods industry, an industry dominated by Nestle, Abbott and MeadJohnson.Houston, TX
Invested July 2018 Fund II |
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Onit makes workflow and process management software, applicable to a company’s General Counsel function, Human Resources, and any business processes where adherence to process is a critical issue.Houston, TX
Invested January 2016 Exited November 2018 Fund I |
| HUVRData performs industrial inspections faster, safer with more actionable data than current methods. HUVRs imaging technology provides our clients with dramatically clearer views of their assets. HUVR’s cloud services allows secure access for our clients so that information can be stored, shared and accessed 24×7. HUVR SaaS Tools allow industrial asset owners to collect, manage and analyze drone AND technician collected data for a complete asset inspection. HUVR’s data analytics engine allows our clients to reduce costs and increase operational efficiencies. HUVR Inspection Services perform industrial asset inspections in the Renewable Energy, Oil and Gas, Ships / Barges / Jack Rigs, Cellular, Bridges / Dams and other Industrial Asset Markets. HUVR’s tools are transformational. Their uniqueness lies in unifying the data sets collected by drones, technicians, engineers and other automated collection devices. The tools produce the richest set of reports, customized to what each constituent within an organization needs to perform their job. The analytics engine provides rich, simple to understand actionable data to make predictive and prescriptive operational decisions to drive down costs.Austin, TX
Invested June 2015 Fund I |
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myLABbox is the first provider of at-home testing for sexually transmitted diseases, with the convenience and privacy of collecting necessary samples at home, and returning them through the mail for a safe, fast, private result, using standard laboratory procedures. Since launching, the company has expanded into other sectors of health testing.Los Angeles, CA
Invested June 2015 Fund I |
| Adient Medical is developing an absorbable inferior vena cava filter to prevent thrombosis. These revolutionary devices can be safely implanted in a manner similar to metallic IVC filters, and then simply dissolve over time, preventing the complications associated with traditional IVC filters.Pearland, TX
Invested May 2014 Fund I |
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| Quad Technologies makes an innovative hydrogel for use in cell selection, in the manufacturing of biologic-based therapeutics. The company was acquired by Bio-Techne in July 2018.Boston, MA
Invested March 2014 Exited July 2018 Fund I |
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Deep Imaging Technologies provides services to use electromagnetic radiation to image the results of fracking operations in oil and gas reservoirs. This unique imaging capability permits operators to accurately assess the topology of the reservoir and the effects of fracking.Tomball, TX
Invested February 2014 Fund I |
| Payouts Network provides loyalty and couponing capabilities linked directly to a customer’s credit card, so that a reward is automatically redeemed when the linked credit card is used for a purchase at a business. The company’s initial customers operate ski resorts through-out the United States.Los Angeles, CA
Invested January 2014 Fund I |
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| Dynamo Micropower is developing a 10kW class gas generator (genset) that can be rapidly deployed in wide ranging applications. Our initial product, the Dynamo Turbocore 7.5 leverages state of the art gas turbine technology in a highly portable package, while being cost competitive with reciprocating gensets on the market today. The Turbocore can run on all manner of fuels from vodka through JP-8, as well as natural gas and propane, and its oil-less bearing system means minimal maintenance requirements during times of need. Furthermore, units can be stored for years and can be brought online at a moment’s notice. With only two moving parts, Dynamo’s ultra-microturbine requires only annual maintenance and provides a significantly longer operating life over reciprocating solutions. By approaching microturbine design with a perspective focused on market price and functional needs, we are developing a simplified architecture that enables further miniaturization and mass scale manufacturing of microturbines.Boston, MA and Houston, TX
Invested December 2013 Exited December 2020 Fund I |
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| TNG Pharmaceuticals is developing a revolutionary veterinary vaccine based on recombinant protein technology. It is designed for vaccination of cattle to specifically disrupt blood-feeding by horn flies (Haematobia irritans), the most economically important livestock pest in the United States and much of the world.Louisville, KY
Invested August 2013 Fund I |
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Cinegif‘s founder invented the cinemagraph, which is still photographs in which a minor and repeated movement occurs, forming a video clip. They are published as an animated GIF or in other video formats, and can give the illusion that the viewer is watching an animation. The company holds patents on this technology, and is currently primarily engaged in enforcing its patent suite. The fund received its first distribution from the company in 2018.Austin, TX
Invested April 2013 Exited August 2018 Fund I |
| Infrastructure Networks provides cellular data communications for the oil patch, enabling human comforts in man camps, and providing critical communications for the digital oilfield and the Internet of Things proliferating in the energy industry.Houston, TX
Invested January 2013 Fund I |
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AdventureLink makes your trip unforgettable. They’ll guide you in booking the perfect trip.Los Angeles, CA
Invested August 2012 Exited August 2016 Fund I |